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Soluble synthetic polymers represent a new group of compounds considered as novel class of therapeutics. Recent results proved that such polymeric macromolecules could exhibit promising biological activity attractive for biomedical research and application. N-(2-hydroxypropyl)methacrylamide copolymer (HPMA) has been used with success in experimental cancer research [1], while Copaxone® a random copolymer of Lys, Glu, Tyr and Ala residues has been proved by FDA against multiple sclerosis in human [2]. Polyamino acids containing negatively charged and aromatic residues at specific ratios appear to bind HIV type 1 V3 loop and neutralise diverse laboratory isolates [3]. Artificial immunogens as vaccine candidates have been produced by free radical induced polymerization of vinyl monomers such as the acryloyl peptides representing Band or T-cell epitopes of relevant proteins [4]. Peptide oligomers containing an (AibLys-Gly)n backbone and epitope sequence at the e -amino group of Lys residue were built up by co-linear solid phase synthesis [5]. Polymers are also developed for modification of proteins to suppress their undesired properties. Therefore protein/peptide conjugates with a polymeric component |
