Synthesis and experimental study of a dextran-ferrite-based magnetically driven nanopreparation as an MRI contrast agent for tumor-feeding vessels

Autor:	A. V. Ivanov, Yu. A. Pirogov, N. A. Brusentsov, A. A. Uchevatkin, V. A. Polyanskii, T. N. Brusentsova
Rok vydání:	2011
Předmět:	Pharmacology medicine.diagnostic_test Chemistry MRI contrast agent Capsule Magnetic resonance imaging 3d scanning chemistry.chemical_compound Nuclear magnetic resonance Dextran In vivo Negative Contrast Agent Drug Discovery medicine Ferrite (magnet)
Zdroj:	Pharmaceutical Chemistry Journal. 45:84-87
ISSN:	1573-9031 0091-150X
Popis:	Dextran-ferrite (DF) nanoparticles were synthesized and the related DF sol was successfully tested in vivo as a negative contrast agent for enhancing early magnetic resonance imaging (MRI) detection of tumor, capsule, and tumor-feeding vessels. Intravenous injection of DF in combination with Magnevist and subsequent T2,T 2 * -weighted 3D scanning gave enhanced MRI images that defined the arrangement and functional state of surface and other vessels feeding capsule and tumor in C57Bl/6j mice with a mammary adenocarcinoma (Ac755) model.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e244c2f0d87ff9b65ba25526de1d4310 https://doi.org/10.1007/s11094-011-0565-3 Zobrazit plný text záznamu Plný text ve formátu PDF