Emerimicins III and IV and their ethylalanine12 epimers. Facilitated chemical-enzymatic synthesis and a qualitative evaluation of their solution structures

Autor:	William C. Hutton, Karol Kociolek, Denise D. Beusen, Urszula Slomczynska, Janusz Zabrocki, Garland R. Marshall, Adam S. Redlinski, Fritz Reusser, Miroslaw T. Leplawy
Rok vydání:	1992
Předmět:	Oligopeptide Stereochemistry Peptaibol General Chemistry Biochemistry Solution structure Catalysis chemistry.chemical_compound Papain Colloid and Surface Chemistry chemistry Peptide synthesis Molecule Epimer Emerimicins
Zdroj:	Journal of the American Chemical Society. 114:4095-4106
ISSN:	1520-5126 0002-7863
DOI:	10.1021/ja00037a010
Popis:	The peptaibol antibiotics, emerimicin III and IV (Ac-Phe 1 -MeA 2 -MeA 3 -MeA 4 -Val 5 -Gly 6 -Leu 7 -MeA 8 -MeA 9 - Hyp 10 -Gln 11 -R-EtA 12 -Hyp 13 -Xxx 14 -Phol 15 , where Xxx=Ala for emerimicin III and Xxx=MeA for emerimicin IV) and their EtA 12 epimers have been synthesized using a combined approach involving solution-phase fragment condensation with a final papain-mediated coupling of the 1-6 and 7-15 fragments
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e243db448525a62595aaa04fac9f8e90 https://doi.org/10.1021/ja00037a010 Zobrazit plný text záznamu