| Autor: |
Hugh C. Vincent, Daniel E. Simon, Stephen S. Ober, Kenneth J. Frederick |
| Rok vydání: |
1958 |
| Předmět: |
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| Zdroj: |
Journal of the American Pharmaceutical Association (Scientific ed.). 47:667-676 |
| ISSN: |
0095-9553 |
| DOI: |
10.1002/jps.3030470915 |
| Popis: |
Extent and type of thixotropic breakdown in aqueous, paste-like, procaine penicillin G preparations designed for intramuscular injection have been measured. The rheological properties of such suspensions are correlated with surface area and particle size distribution of the constituent powders. Certain thixotropic parameters of repository preparations are related to the nature of the depots formed in rabbit muscle and with product injectability and effectiveness in the human, as revealed by blood level data. A dilute gelatin gel has been found useful in forecasting and illustrating the nature of depots formed in muscle tissue. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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