| Popis: |
It is well recognized that changes in electrophoretic patterns of serum or plasma proteins occur in various types of liver diseases.l-l0 To date, however, only a few isolated studies of these proteins have been reported in patients with diffuse hepatic necrosis.s, 9 Systematic attempt has not yet been made to evaluate the results in a large series of proved cases. * We describe in the present paper the electrophoretic pattern of the plasma proteins seen in 10 cases of diffuse liver necrosis in all of which extensive anatomico-pathologic studies of the liver were made. The exact diagnosis of such cases being frequently impossible solely on the bases of the clinical picture and usual tests, we preferred grouping them according to the anatomicopathologic features, considering three criteria: (1) Diffuse or focal, according to the extension of the lesion throughout the liver as a whole. In the present studies we will consider only the diffuse cases. (2) Massive or zonal, according to the extension of the lesion throughout the hepatic lobule.n (3) Fulminant or protracted, according to the approximate duration of the lesions. We based the distinction between fulminant and protracted forms on the absence or presence of regeneration, degree of bile duct proliferation, reticulum collapse, and widening of sinusoids. However, no one of these criteria alone allows a positive judgment concerning the length of the process. In 5 cases (1. A. P., C. C., B. C. M., A. J., and J. A. Q.) the pathologic features were suggestive of a viral etiology, according to the criteria of Lucke and Mallory.13 |
