| Autor: |
Patricia Price, Elizabeth McKinnon, S. Phung, Niamh M. Keane, Martyn A. French |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
HIV Medicine. 8:148-155 |
| ISSN: |
1464-2662 |
| DOI: |
10.1111/j.1468-1293.2007.00445.x |
| Popis: |
Objectives: HIV-infected patients responding to combination antiretroviral therapy (ART) after experiencing severe immunodeficiency may exhibit persistent immune defects and occasionally experience opportunistic infections (OIs) despite increased CD4 T-cell counts. The investigation of immune defects in such patients was examined in this study. Methods: CD4 effector memory T-cell (T em-cell) function [assessed by blood cytomegalovirus (CMV) interferon-γ (IFN-γ) enzyme-linked immunosorbent spot-forming cell assay (ELISPOT) counts] and B-cell dysregulation [assessed by serum immunoglobulin A (IgA) and IgE levels] were examined in 27 patients with increased CD4 T-cell counts after receiving ART for over 2 years. Two of these patients and one other had developed OIs on ART and are described in detail. Results: Serum levels of IgA and IgE were higher than reference intervals (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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