Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers
| Autor: | Caigan Du, Haiming D. Luo, Megan K. Levings, Christine M. Wardell, Kevin Rey, Jayachandran N. Kizhakkedathu, Lyann Sim, Jonathan C. Choy, Qiunong Guan, Stephen G. Withers, Zheng J. Zhang, Franklin Tam, Mahdis Monajemi, Haisle Moon, Majid Mojibian, Ashani Montgomery, Erika M. J. Siren, Winnie Enns, Jiao Jing Wang |
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| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Biomedical Engineering Medicine (miscellaneous) Adhesion (medicine) Bioengineering Regenerative medicine Organ transplantation 03 medical and health sciences 0302 clinical medicine Tissue engineering Medicine 030304 developmental biology 0303 health sciences Kidney business.industry medicine.disease 3. Good health Computer Science Applications Transplantation surgical procedures operative medicine.anatomical_structure business Ligation Perfusion 030215 immunology Biotechnology |
| Zdroj: | Nature Biomedical Engineering. 5:1202-1216 |
| ISSN: | 2157-846X |
| DOI: | 10.1038/s41551-021-00777-y |
| Popis: | Systemic immunosuppression for the mitigation of immune rejection after organ transplantation causes adverse side effects and constrains the long-term benefits of the transplanted graft. Here we show that protecting the endothelial glycocalyx in vascular allografts via the enzymatic ligation of immunosuppressive glycopolymers under cold-storage conditions attenuates the acute and chronic rejection of the grafts after transplantation in the absence of systemic immunosuppression. In syngeneic and allogeneic mice that received kidney transplants, the steric and immunosuppressive properties of the ligated polymers largely protected the transplanted grafts from ischaemic reperfusion injury, and from immune-cell adhesion and thereby immunocytotoxicity. Polymer-mediated shielding of the endothelial glycocalyx following organ procurement should be compatible with clinical procedures for transplant preservation and perfusion, and may reduce the damage and rejection of transplanted organs after surgery. Protection of the endothelial glycocalyx in vascular allografts via the enzymatic ligation of immunosuppressive glycopolymers prevents allograft rejection after transplantation in the absence of systemic immunosuppression. |
| Databáze: | OpenAIRE |
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