Boronic acid substituted viologen based optical sugar sensors: modulated quenching with viologen as a method for monosaccharide detection

Autor:	Bakthan Singaram, Ritchie A. Wessling, Jeff T. Suri, Frank E. Cappuccio, Jason N. Camara
Rok vydání:	2002
Předmět:	chemistry.chemical_classification Aqueous solution Quenching (fluorescence) Organic Chemistry Viologen Photochemistry Biochemistry Fluorescence Pyranine chemistry.chemical_compound chemistry Drug Discovery medicine Monosaccharide Boronic acid Visible spectrum medicine.drug
Zdroj:	Tetrahedron Letters. 43:1139-1141
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(01)02366-8
Popis:	In our search for an optical glucose sensor we have found that the combination of pyranine 1 and a boronic acid substituted benzyl viologen (o-BBV, 2 ) signals monosaccharides in the range of 0–1800 mg/dL. The quenching ability of o-BBV is modulated upon sugar binding, which in turn alters the fluorescence of pyranine. The system utilizes a dye that is active in the visible spectrum, operates in aqueous solution at pH 7.4, and is highly sensitive to glucose in the physiological range.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e2150927ecbfeb760d985fb37835d718 https://doi.org/10.1016/s0040-4039(01)02366-8 Zobrazit plný text záznamu Full Text from ScienceDirect