ChemInform Abstract: Diastereoselective Synthesis of N-Protected β-Amino-α-hydroxyacids (Norstatines) from Urethane N-Carboxyanhydrides (UNCAs)

Autor:	Joëlle Paris, Jean Martinez, Jean-Alain Fehrentz, A. Loffet, Catherine Pothion, Patrick Audin
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Alcohol General Medicine Medicinal chemistry
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199936217
Popis:	β-Amino-α-hydroxyacids (norstatines) are prepared from urethane N-protected carboxyanhydrides (UNCAs); the key step is the diastereoselective reduction of a keto-acetylenic compound, which lead is, with syn diastereoselectivity, to the corresponding propargylic alcohol.
Databáze:	OpenAIRE
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