Bullet for periodontal disease in future: Chemically modified tetracyclines

Autor:	Ameet Mani, Harish Saluja, Shivani Sachdeva
Rok vydání:	2021
Předmět:	Periodontal disease business.industry Chemistry Dentistry business Molecular Biology Applied Microbiology and Biotechnology Biotechnology
Zdroj:	Journal of Cellular Biotechnology. 7:111-117
ISSN:	2352-3697 2352-3689
DOI:	10.3233/jcb-210040
Popis:	Chronic periodontitis is nowadays popularly regarded as Dysbiosis, [1] which causes destruction of tissues rich in collagen like periodontal ligament, alveolar bone and gingival connective tissue. The oral biofilm comprises many periodontal pathogens better regarded as ‘triggers’ in causing chronic periodontitis. Since, not everyone will be affected in the same manner due to periodontal pathogens. Some might not elicit a host response while, the others might have exaggerated response. So, host modulation therapy came into existence to counteract the exaggerated host response. The chemically modified tetracyclines (CMTs) have emerged to inhibit the inflammatory response or to reduce the collagenolytic activity of host. Though a derivative of tetracyclines, it still lacks an antimicrobial action and hence, can be used for periodontitis for longer duration with no adverse effects of gastrointestinal toxicity which parent tetracyclines have.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e20006b5b8c017feec5e4f7a1bb486d6 https://doi.org/10.3233/jcb-210040 Zobrazit plný text záznamu