UV365 light promoted catalyst-free synthesis of pyrimido[4,5-b]quinoline-2,4-diones in aqueous-glycerol medium
| Autor: | Rishanlang Nongkhlaw, George Kupar Kharmawlong, Geetmani Singh Nongthombam, John Elisa Kumar |
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| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Aqueous solution Barbituric acid 010405 organic chemistry Chemistry Aryl Quinoline General Chemistry 010402 general chemistry 01 natural sciences Aldehyde Combinatorial chemistry Environmentally friendly Catalysis 0104 chemical sciences Solvent chemistry.chemical_compound Materials Chemistry |
| Zdroj: | New Journal of Chemistry. 42:9436-9442 |
| ISSN: | 1369-9261 1144-0546 |
| Popis: | Herein, a highly efficient and environmentally benign protocol for the synthesis of biologically important pyrimido[4,5-b]quinolinone-2,4-diones from aromatic amines, barbituric acid and aryl aldehyde is reported. This process takes place at room temperature under direct irradiation from a UV365 light source in the absence of a photocatalyst. The reported approach has several advantages such as high yield, clean reaction conditions, chromatography-free synthesis and the use of a cheap water–glycerol solvent system, which is also an environmentally friendly solvent. The applicability of this protocol for the large-scale synthesis of pyrimido[4,5-b]quinolinone-2,4-diones without wasting any expensive chemicals is an added advantage. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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