Simultaneous analysis of octylmethoxycinnamate and butylmethoxydibenzoylmethane in sunscreen products by a validated UV-spectrophotometric method
| Autor: | A.A.M. Prince, S. Lavakumar, P.A. Vivekanand |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
010302 applied physics
Solvent system Chromatography Relative standard deviation Octyl methoxycinnamate 02 engineering and technology 021001 nanoscience & nanotechnology 01 natural sciences Oil in water chemistry.chemical_compound chemistry 0103 physical sciences Methanol 0210 nano-technology Water in oil |
| Zdroj: | Materials Today: Proceedings. 36:893-897 |
| ISSN: | 2214-7853 |
| DOI: | 10.1016/j.matpr.2020.07.025 |
| Popis: | In this paper we report, an accurate, rapid, simple and an inexpensive method for the determination of Octyl methoxycinnamate and Butylmethoxydibenzoylmethane in sunscreen products using UV–Vis spectrophotometer. The method is validated as per ICH guidelines. The solvent system is methanol, with λmax of 310 nm for OMC and 357 nm for BMDM, linearity range of OMC is 1.01 to 10.12 µg/ml (R2 = 0.9997) and BMDM is 1.00 to 10.02 µg/ml (R2 = 0.9996), The % recovery of OMC (98.04–99.69) and relative standard deviation (%RSD, 0.54) and % recovery of BMDM (95.77–97.31) and relative standard deviation (%RSD, 0.55), highlights the accuracy of the method developed. The method is compatible to wide variety of products composed of oil in water and water in oil emulsions containing low, intermediate, and high OMC and BMDM levels (1%, 2%, and 4%) gave good recovery. This method is suitable for meeting dynamic need of formulation development and suitable for quality assurance of all types of skincare products containing OMC and BMDM. |
| Databáze: | OpenAIRE |
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