| Autor: |
Jarrod MacFarlane, Eric E. Poole, Monte Squiers, Maxwell V. Phillips, Matthew R. Steensma, Andrew Albert, Jeffrey Cassidy, Bennett W. Hartley |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-245713/v1 |
| Popis: |
Background: Unicameral bone cysts (UBCs) are frequently associated with pathologic fracture due to aggressive osteolysis. Methods/Results: We present a case series (n=5) with complex or refractory bone cysts treated with doxycycline injections that exhibited increased ossification and symptom resolution at short term follow up with minimal side effects. Conclusions: In addition to its antibiotic properties, doxycycline is also known to inhibit matrix metalloproteinases, angiogenesis, and osteoclast activity suggesting that UBCs are dependent on MMP, VEGF or RANKL-mediated osteolysis. Further investigation is warranted regarding the use of doxycycline injections in UBCs. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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