THE VALUE OF THE GLUCOSE TOLERANCE TEST, THE INSULIN TOLERANCE TEST, AND THE GLUCOSEINSULIN TOLERANCE TEST IN THE DIAGNOSIS OF ENDOCRINOLOGIC DISORDERS OF GLUCOSE METABOLISM1

Autor: Patricia H. Smith, Fuller Albright, Russell Fraser
Rok vydání: 1941
Předmět:
Zdroj: The Journal of Clinical Endocrinology & Metabolism. 1:297-306
ISSN: 1945-7197
0021-972X
DOI: 10.1210/jcem-1-4-297
Popis: CARBOHYDRATE METABOLISM is influenced by I many tissues, notably pancreatic islets, adrenal medulla, adrenal cortex, anterior pituitary, muscles and liver. As an aid in the diagnosis of various diseases, it has for a long time been useful to study the glucose content of the blood. Thus, the determination of this under fasting conditions may at once give the clue to the diagnosis. In many instances, however, because of compensatory adjustments the fasting level is normal in spite of a definite disturbance in the sugar metabolism (e.g., mild diabetes) and it is necessary to subject the sugar-regulatory mechanism to some selected strain in order to elicit an abnormality. What strain one chooses naturally should depend on what disorder one suspects. For example, if looking for hypo-insulinism one would test the ability of the body to adjust to an alimentary hyperglycemia, that is one would perform the ordinary sugar tolerance test. If it turned out that the patient had a decreased responsiveness to hyperglyce...
Databáze: OpenAIRE