NADPH AND NADH OXIDATION BY GUINEA PIG POLYMORPHONUCLEAR LEUCOCYTES

Autor:	Juda Hirsch Quastel, G. Y. N. Iyer
Rok vydání:	1963
Předmět:	chemistry.chemical_classification Phagocytosis chemistry.chemical_element General Medicine Oxygen Guinea pig chemistry.chemical_compound Enzyme chemistry Biochemistry Enzyme system Oxidizing agent NAD+ kinase Hydrogen peroxide
Zdroj:	Canadian Journal of Biochemistry and Physiology. 41:427-434
ISSN:	0576-5544
DOI:	10.1139/o63-051
Popis:	A homogenate of guinea pig polymorphonuclear leucocytes contains an enzyme system capable of oxidizing, in presence of oxygen, NADPH and NADH with the formation of hydrogen peroxide. The enzyme is much more active towards NADPH than to NADH. The presence of manganese ions strongly enhances the oxidase activity. It is suggested that the release of the NADPH oxidase in the leucocytes, during phagocytosis, accounts for the stimulation of the hexose monophosphate pathway that occurs in phagocytosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e1e120102ad894d9e5b27f313eda9aee https://doi.org/10.1139/o63-051 Zobrazit plný text záznamu