Synthesis and antiviral activity of adamantyl-containing phosphonous and phosphinic acids

Autor:	Alexander N. Reznikov, O. V. Savinova, Yu. N. Klimochkin, N. L. Bogdanova, E. I. Boreko, S. V. Orlova
Rok vydání:	2014
Předmět:	Hypophosphorous acid viruses Adamantane Phosphonous Acids Sodium hypophosphite Influenza a General Chemistry medicine.disease_cause Virus chemistry.chemical_compound Herpes simplex virus chemistry Phosphinic Acids medicine Organic chemistry
Zdroj:	Russian Journal of General Chemistry. 84:1524-1530
ISSN:	1608-3350 1070-3632
Popis:	The method of adamantly-containing phosphonous and phosphinic acids preparation, based on radical addition of hypophosphorous acid and sodium hypophosphite to unsaturated derivatives of adamantane, has been developed. Unsymmetrical phosphinic acids have been prepared by reacting bistrimetylsilyl esters of phosphonous acids with halides. The obtained phosphinic acids exhibit antiviral activity against herpes simplex virus, influenza A (H5N1), respiratory syncytial virus, and adenovirus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e1d8a526a3fa8398bbdf6cd47fbf4a1f https://doi.org/10.1134/s1070363214080143 Zobrazit plný text záznamu Plný text ve formátu PDF