Abstract 16: Tribbles1 Regulates Hepatic Lipogenesis in Mice through Post-Translational Regulation of C/EBPα

Autor:	Robert C Bauer, Makoto Sasaki, Daniel M Cohen, Jian Cui, Mikhaila A Smith, David J Steger, Daniel J Rader
Rok vydání:	2015
Předmět:	Cardiology and Cardiovascular Medicine
Zdroj:	Arteriosclerosis, Thrombosis, and Vascular Biology. 35
ISSN:	1524-4636 1079-5642
Popis:	Tribbles1 (TRIB1) was recently identified in genome-wide association studies as being associated with plasma levels of VLDL, HDL, LDL, and TG as well as coronary artery disease in humans. Here we report studies in a Trib1 liver-specific knockout mouse (Trib1_LSKO) created via AAV-mediated delivery of Cre recombinase into mice with a floxed allele of Trib1. Four weeks after infection, Trib1_LSKO mice exhibit a 25% increase in liver weight (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e1d774185c656af4035ade00d86878c1 https://doi.org/10.1161/atvb.35.suppl_1.16 Zobrazit plný text záznamu