Label-Free Thrombin Detection Using a Tapered Fiber-Optic Interferometric Aptasensor

Autor:	Dandan Sun, Tuan Guo, Li-Peng Sun, Bai-Ou Guan
Rok vydání:	2019
Předmět:	Optical fiber Materials science business.industry Guided-mode resonance Aptamer technology industry and agriculture Atomic and Molecular Physics and Optics law.invention Interferometry Scanning probe microscopy law Optoelectronics Surface plasmon resonance business Biosensor Refractive index
Zdroj:	Journal of Lightwave Technology. 37:2756-2761
ISSN:	1558-2213 0733-8724
Popis:	Aptamer biosensor for label-free thrombin detection based on a tapered fiber-optic interferometer has been proposed and demonstrated. The biosensor probe can be easily fabricated by tapering a commercial double-cladding fiber down to 5 μm in diameter and it provides a high refractive index sensitivity of 1660 nm/RIU. The changes are determined by tracing the wavelength shift of the dip in the transmission spectrum with variable surrounding refractive index. With the help of the surface functionalization of thrombin-binding aptamers, the proposed fiber-optic biosensor proves its capability in label-free detection of thrombin with a lowest detectable concentration of 0.1 μm, together with high specificity in various concentrations of pure and mixed thrombin solutions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e1ceeed6bee0ce2bcffcc7a37d59fd21 https://doi.org/10.1109/jlt.2018.2878762 Zobrazit plný text záznamu