Metered-Dose Inhalers: The Specified Number of Sprays

Autor:	William A. Greisner, Arthur Bergner, Renee K. Bergner
Rok vydání:	1993
Předmět:	medicine.medical_specialty business.industry Inhaler Anesthesia Medicine General Medicine business Intensive care medicine medicine.disease Asthma
Zdroj:	JAMA: The Journal of the American Medical Association. 269:1506-1506
ISSN:	1538-3598 0098-7484
DOI:	10.1001/jama.1993.03500120044018
Popis:	To the Editor. —Asthma morbidity and mortality rates are on the rise and their causes are currently being addressed. 1 The appropriate role and use of β-agonist inhalers are being questioned. 2 We would like to call attention to a problem associated with the use of metered-dose inhalers (MDIs). As is shown in the Table, MDIs contain sufficient medication for a specified number of inhalations. 3 We believe that some of the exacerbations of asthma in our patients occurred when they continued to use their MDIs beyond the specified number of sprays. As an inhaler is used, "the dose emitted by a large number of valves currently used seems to decline as the product is exhausted." 4 When about 15% of the original amount of sus pension remains, the meter chamber does not fill uniformly and subsequent doses fall below acceptable limits. 4 The liquid propellant and decreasing doses of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e1cb194abf907137a4d55a551db6f0e0 https://doi.org/10.1001/jama.1993.03500120044018 Zobrazit plný text záznamu