Manifestaciones cutáneas de la enfermedad injerto versus huésped en una población pediátrica y de adultos jóvenes
| Autor: | Ana Giachetti, Magdalena Sojo, Ana Carbajosa, Monica Makiya, Cecilia Martino, Roberta Calvano, Paula Boggio, María Florencia Scacchi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
education.field_of_study business.industry Population Clinical manifestation Disease medicine.disease Dermatology surgical procedures operative Graft-versus-host disease immune system diseases Pediatrics Perinatology and Child Health medicine Maculopapular rash medicine.symptom Young adult business Complication education Morphea |
| Zdroj: | Archivos Argentinos de Pediatria. 118 |
| ISSN: | 0325-0075 |
| DOI: | 10.5546/aap.2020.e468 |
| Popis: | Bone marrow transplant is a potentially curative therapy for several diseases, and allogeneic bone marrow transplant is the most commonly indicated type for leukemias. Graft versus host disease (GVHD) is the main complication of allogeneic bone marrow transplant. In both acute and chronic GVHD, the skin is the most frequently involved organ. The objective of this study was to analyze cutaneous manifestations of this disease. Retrospective and descriptive study that included 59 transplanted patients aged 0 to 20 years. In 50 cases allogeneic bone marrow transplant was performed. Twenty-five patients developed GVHD (17 acute disease and 8 chronic disease) and 24 of them had cutaneous involvement. According to the literature, skin compromise was the commonest clinical manifestation of GVHD. Main finding in acute GVHD in our series was the erythematous maculopapular rash, while in chronic GVHD they were sclerotic lesions resembling morphea. |
| Databáze: | OpenAIRE |
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