Context-induced relapse to cocaine seeking after punishment-imposed abstinence is associated with activation of cortical and subcortical brain regions
| Autor: | Yann Pelloux, Angelica Minier-Toribio, Carlo Cifani, Jennifer M. Bossert, Jennifer K. Hoots, Sweta Adhikary, Jennifer A. Martin, Yavin Shaham |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Lateral hypothalamus media_common.quotation_subject Medicine (miscellaneous) Context (language use) Nucleus accumbens Ventral pallidum 03 medical and health sciences 0302 clinical medicine Dorsal raphe nucleus medicine Psychiatry media_common Pharmacology business.industry Abstinence Ventral tegmental area Psychiatry and Mental health 030104 developmental biology medicine.anatomical_structure nervous system business Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery Basolateral amygdala |
| Zdroj: | Addiction Biology. 23:699-712 |
| ISSN: | 1355-6215 |
| Popis: | We recently developed a rat model of context‐induced relapse to alcohol seeking after punishment‐imposed abstinence to mimic relapse after self‐imposed abstinence due to adverse consequences of drug use. Here, we determined the model’s generality to cocaine and have begun to explore brain mechanisms of context‐induced relapse to cocaine seeking after punishment‐imposed abstinence, using the activity marker Fos. In exp. 1, we trained rats to self‐administer cocaine (0.75 mg/kg/infusion, 6 hours/day, 12 days) in context A. Next, we transferred them to context B where for the paired group, but not unpaired group, 50 percent of cocaine‐reinforced lever presses caused aversive footshock. We then tested the rats for cocaine seeking under extinction conditions in contexts A and B. We also retested them for relapse after retraining in context A and repunishment in context B. In exp. 2, we used Fos immunoreactivity to determine relapse‐associated neuronal activation in brain regions of rats exposed to context A, context B or neither context. Results showed the selective shock‐induced suppression of cocaine self‐administration and context‐induced relapse after punishment‐imposed abstinence in rats exposed to paired, but not unpaired, footshock. Additionally, context‐induced relapse was associated with selective activation of dorsal and ventral medial prefrontal cortex, anterior insula, dorsal striatum, basolateral amygdala, paraventricular nucleus of the thalamus, lateral habenula, substantia nigra, ventral subiculum, and dorsal raphe, but not nucleus accumbens, central amygdala, lateral hypothalamus, ventral tegmental area and other brain regions. Together, context‐induced relapse after punishment‐imposed abstinence generalizes to rats with a history of cocaine self‐administration and is associated with selective activation of cortical and subcortical regions. |
| Databáze: | OpenAIRE |
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