Hepatotoxicity and hepatotoxicants: A systematic review

Autor:	Hariprasad Mg, N. C Nagalakshmi, Hemalatha S, Narayan Sah Sonar
Rok vydání:	2020
Předmět:	Drug Liver injury Clinical pharmacology Computer science media_common.quotation_subject Azathioprine Disease Pharmacology medicine.disease law.invention chemistry.chemical_compound Immune system chemistry law Galactosamine Toxicity medicine media_common medicine.drug
Zdroj:	Indian Journal of Pharmacy and Pharmacology. 6:107-112
ISSN:	2393-9087 2393-9079
DOI:	10.18231/j.ijpp.2019.024
Popis:	Liver act as metabolic factory of the body and metabolism of virtually every foreign substance. Its functioning is crucial for health and disease. Chemicals that cause liver injury are called hepatotoxicants. More than 950 drugs have been implicating in causing liver injury and were withdrawn from the market. Mechanism of hepatotoxicity induced by drug, immune based and genetic based toxicity. The drug models which are applied to study hepatotoxicity are Paracetamol, CCl4, Galactosamine, Alcohol, Azathioprine, Rantidine and different classof drugs cause acute and chronic liver injury. Keywords: Hepatotoxicity, Hepatotoxicants, Mechanism, Liver injury, Drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e1b15ce9735a8333b23845e3f7830052 https://doi.org/10.18231/j.ijpp.2019.024 Zobrazit plný text záznamu