The relationship between uric acid and dyslipidemia in type 2 diabetic patients with urolithiasis
| Autor: | Devasia Dona, V Nimisha |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Baghdad Journal of Biochemistry and Applied Biological Sciences. |
| ISSN: | 2706-9915 2706-9907 |
| Popis: | Background and objective: Diabetes mellitus (DM) is characterized by insulin resistance which canincrease the risk of kidney stone formation. This study aimed to find out the association between serum levels of uric acid and lipid profile in DM patients with urolithiasis in comparison to those without. Methods: This cross-sectional study was conducted at P K Das institute of medical sciences,Vaniamkulam, Palakkad, Kerala, India with the approval of the institutional ethical review committee for human studies. A total of 60 patients were included in the study.Group A patients with DM and urolithiasis, and group B patients with DM but without urolithiasis. Biochemical parameters studied were glucose, urea, creatinine, uric acid, creatinine, serum uric acid to creatinine ratio, lipid profile, HbA1c, and triglyceride glucose index. Statistical analysis was done using SPSS version 21. Results: We found a significant increase in uric acid, urea, serum uric acid to creatinine ratio, and triglyceride glucose index levels in diabetic urolithiasis cases as compared to diabetes mellitus cases without urolithiasis. We also found that total cholesterol, triglycerides, LDL-C, and VLDL-C levels were significantly increased, and HDL-cholesterol was significantly decreased in diabetic urolithiasis cases. Serum uric acid was positively correlated with total cholesterol, triglycerides, LDL-C, and VLDL-C and negatively correlated with HDL-C in diabetic urolithiasis cases. Conclusions: From this study, it is demonstrated that patients with diabetic urolithiasis are having high insulin resistance, altered lipoprotein metabolism, and increased level of serum uric acid. The dyslipidemia components are strongly associated with increased uric acid. |
| Databáze: | OpenAIRE |
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