Non-peptide fibrinogen receptor antagonists. 4. Proposed three-dimensional requirements in centrally constrained inhibitors

Autor:	Melissa S. Egbertson, Guixiang Zhang, A.M. Naylor, L.M. Vassallo, George D. Hartman, Robert J. Gould, Laura A. Birchenough
Rok vydání:	1994
Předmět:	Chemistry Fibrinogen receptor Stereochemistry Organic Chemistry Clinical Biochemistry Antagonist Pharmaceutical Science Ligand (biochemistry) Biochemistry Non peptide Drug Discovery Molecular Medicine Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 4:1841-1846
ISSN:	0960-894X
Popis:	A three-dimensional description of ligand conformations consistent with GPIIbIIIa antagonist activity was developed from a systematic conformational search of centrally-constrained fibrinogen receptor antagonists.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e1a9323f802c7beea12584480e88410d https://doi.org/10.1016/s0960-894x(01)80381-4 Zobrazit plný text záznamu