Spirometry in adult systemic lupus erythematosus and its relation with disease duration: A cross-sectional study in Eastern India
| Autor: | Prasenjit Majumdar, Subhankar Haldar, Md. Mahboob Alam, Ardhendu Mazumdar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Spirometry
medicine.medical_specialty Vital capacity medicine.diagnostic_test Respiratory distress Physiology business.industry Cross-sectional study Interstitial lung disease respiratory system medicine.disease FEV1/FVC ratio Chronic cough Internal medicine Medicine General Pharmacology Toxicology and Pharmaceutics medicine.symptom business Subclinical infection |
| Zdroj: | National Journal of Physiology, Pharmacy and Pharmacology. :1 |
| ISSN: | 2320-4672 |
| DOI: | 10.5455/njppp.2019.9.0622222062019 |
| Popis: | Background: Although symptomatic interstitial lung disease (ILD) complicates in 38% of patients with systemic lupus erythematosus (SLE), subclinical ILD is common and has been described in up to one-third of patients. Aims and Objectives: Objective was spirometric evaluation of adult SLE patients having no pulmonary symptoms. Materials and Methods: A cross-sectional study was carried out involving adult SLE. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC ratio, forced expiratory flow (FEF) between 25 and 75% of vital capacity (FEF2575%), and peak expiratory flow rate (PEFR) were measured. Pearsons correlation analysis was used to determine the correlation of disease duration with spirometric parameters. Results: Of 74 patients (age 1850 years), six were male. Mean age, height, and weight were 29.65 years, 154.1 cm, and 52.75 kg, respectively. Mean duration of the disease was 4.5 years. Sixty patients (five males among them) were in remission with SLE Disease Activity Index score of 0. None had chronic cough or any respiratory distress at rest or with day-to-day activities. Overall, 34 (46%) patients had normal spirometry. About 56% of female and 33% of male patients had abnormal spirometry. About 49% of female patients had restrictive pattern of abnormality while 9% had obstructive disease. All patients had normal PEFR. Disease duration did not significantly correlate with any of the spirometric parameters or their percent-predicted values. Conclusion: Periodic spirometry of adult SLE patients can be a cost-effective alternative in detecting subclinical pulmonary changes. |
| Databáze: | OpenAIRE |
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