| Popis: |
Vitamin D is important for bone health and is also involved in maintaining the immune system and cell proliferation. Vitamin D status is a major healthcare concern worldwide. Gene variants, involved in vitamin D metabolism, may be associated with vitamin D status and the effectiveness of vitamin D supplementation. The aim of this work was to analyze the association of VDR rs7975232, rs1544410, rs731236, rs2228570 and rs11568820, MTHFR rs1801133 gene variants with the 25(OH)D level in Belarusian women. In total, 602 individuals, meeting the inclusion criteria, were recruited into the study. The study results demonstrated an association of the rs1544410 T/T and rs731236 G/G variants with an increased 25(OH)D level, and rs11568820 A/G + A/A and rs1801133 A/A with a reduced 25(OH)D level. G-G-G allelic combination carriers had a significantly increased (β = 3.5; 95 CI 1.4-5.7, p = 0.0015) vitamin D level. The identified markers may play an important role in optimizing vitamin supplementation and preventing complex diseases. |
