New initiatives in the standardization of protein measurements
| Autor: | Francesco Dati, John Whicher, M. A. Johnson, Soren Blirup-Jensen, Anthony Milford Ward, Anders Carlstrom, P J Svendsen, S. Baudner, Robert F. Ritchie, Jacques Bienvenu |
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| Rok vydání: | 1996 |
| Předmět: | |
| Zdroj: | Pure and Applied Chemistry. 68:1851-1856 |
| ISSN: | 1365-3075 0033-4545 |
| Popis: | Unlike assays for ions and small molecules plasma protein measurements depend entirely on comparison of a test sample with a calibrant, known as a reference material or standard. Owing to the innate molecular heterogeneity of plasma proteins it is often impossible to ensure that the calibrator is identical in its behaviour in measurement systems to the test sample. Despite. these hndamental limitations it is clear that internationally agreed calibrants are the only way to improve consistancy of reporting of protein values in biological fluids between methods and laboratories. Unfortunately, only international units are not subject to contention and the use of mass values which are not internationally agreed, and are re-ascribed during the life of a standard, has jeopardised the value of international calibrants. If mass values are used it must be accepted that they are, to some extent, arbitrary. |
| Databáze: | OpenAIRE |
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