Inhibition of Adrenal Cortical Secretion by Amino-glutethimide in Dogs1

Autor:	Robert L. Trouy, R. Sidney Wilroy, Alvro M. Camacho, A. Ainsworth Hagen
Rok vydání:	1968
Předmět:	medicine.medical_specialty business.industry Cholesterol Dehydroepiandrosterone Venous Plasma Glutethimide chemistry.chemical_compound Endocrinology chemistry Corticosterone Internal medicine medicine Pregnenolone Secretion business medicine.drug Hydrocortisone
Zdroj:	Endocrinology. 83:56-60
ISSN:	1945-7170 0013-7227
Popis:	The acute effect of intravenous administration of amino-glutethimide (25, 50, 75 mg/kg of body wt) on adrenal venous plasma 17-hydroxycorticoid secretion has been studied i n the dog. In spite of a continuous ACTH infusion, each injection of amino-glutethimide produced a prompt fall in the secretion of 17-hydroxycorticoids. Control values were not regained 2 hr following amino-glutethimide. Fractionation of the adrenal venous plasma samples for individual steroids after amino-glutethimide administration revealed a decrease in cortisol and corticosterone with no detectable pregnenolone, 17-hydroxypregnenolone, progesterone, 17-hy-droxyprogesterone, dehydroepiandrosterone, de-oxycorticosterone, and substance S. These observations, along with previous findings of increased adrenal cholesterol and lipid content, are in keeping with the view that amino-glutethimide interferes with the conversion of cholesterol to pregnenolone in the dog. (Endocrinology 83: 56, 1968)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e16da4c13fffcf75228df2fb59a1ae96 https://doi.org/10.1210/endo-83-1-56 Zobrazit plný text záznamu