Synthesis of a 2,5-diaryloxazoline as a potential platelet-activating factor antagonist

Autor:	Norton P. Peet, Eileen F. Heminger, Joseph P. Burkhart, R. J. Broersma
Rok vydání:	1994
Předmět:	Acylation chemistry.chemical_compound chemistry Organic Chemistry Antagonist Biological activity Platelet Oxazoline Pharmacology Platelet activating factor antagonist
Zdroj:	Journal of Heterocyclic Chemistry. 31:419-423
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570310229
Popis:	2,5-Bis-(3,4,5-trimethoxyphenyl)-2-oxazoline (5, MDL 100,270) was desi- gned as a potential plateletactivating factor (PAF) antagonist on the basis of computer modeling comparison studies with known PAF antagonis- ts. An efficient, four-step synthesis of oxazoline (5) was developed, starting from 3,4,5-trimethoxybenzaldehyde (6). Oxazoline (5) was found to inhibit the PAF-induced aggregation of human platelets with an IC 50 value of 708 μM
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e16c0075446b6a990ce12d14d24f8f5f https://doi.org/10.1002/jhet.5570310229 Zobrazit plný text záznamu Plný text