Efficacy ofTrans-cinnamaldehyde and Eugenol in ReducingAcinetobacter baumanniiAdhesion to and Invasion of Human Keratinocytes and Controlling Wound InfectionIn Vitro
| Autor: | Meera Surendran-Nair, Kumar Venkitanarayanan, Deepti Prasad Karumathil |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pharmacology biology 030106 microbiology Biofilm biochemical phenomena metabolism and nutrition Confocal scanning microscopy biology.organism_classification In vitro Acinetobacter baumannii Microbiology law.invention Eugenol 03 medical and health sciences chemistry.chemical_compound Real-time polymerase chain reaction chemistry In vivo Confocal microscopy law |
| Zdroj: | Phytotherapy Research. 30:2053-2059 |
| ISSN: | 0951-418X |
| DOI: | 10.1002/ptr.5713 |
| Popis: | The study investigated the efficacy of two natural, plant-derived antimicrobials (PDAs), namely trans-cinnamaldehyde (TC), and eugenol (EG) for decreasing Acinetobacter baumannii adhesion to and invasion of human keratinocytes (HEK001). Moreover, the efficacy of two PDAs for inhibiting A. baumannii biofilm formation was determined using an in vitro collagen matrix wound model. Additionally, the effect of TC and EG on A. baumannii biofilm architecture was visualized using confocal scanning microscopy. Further the effect of both PDAs on genes critical for biofilm synthesis was determined using real-time quantitative polymerase chain reaction. Both TC and EG significantly reduced A. baumannii adhesion and invasion to HEK001 by ~2 to 3 log10 CFU/mL (p |
| Databáze: | OpenAIRE |
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