EFFECT OF CHEMICALLY-SYNTHESIZED SILVER NANOPARTICLES (AG-NP) ON GLYCEMIC AND LIPIDEMIC STATUS IN RAT MODEL
| Autor: | Elham Ghavidel Aghdam, Alireza Lotfi, Mohammad Narimani-Rad |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Materials science Dose medicine.diagnostic_test Triglyceride Rat model Metabolism Placebo Silver nanoparticle 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Endocrinology chemistry 030220 oncology & carcinogenesis Internal medicine medicine Lipid profile Glycemic |
| Zdroj: | IFMBE Proceedings ISBN: 9789811041655 |
| DOI: | 10.1007/978-981-10-4166-2_25 |
| Popis: | The aim of present study was to investigate the effects of chemically synthesized of silver nanoparticles (Ag-NP) using citrate on selected blood biochemical parameters includes glucose, total cholesterol, triglyceride and total protein in rats model. In this study Ag-NP was synthesized with the usage of chemical reduction method. Laboratory rats were divided into four groups; control, placebo, and groups received 100 and 200 mg/kg BW of Ag-NP. Blood samples were taken, 15 days after administration, and separated serum was used for determination of biochemical measures. Greater dosage of Ag-NP (200 mg/ kg BW) causes mortality in experimental group, due to possible toxic effect of chemically synthesizedAg-NP. In serum biochemical measures infusion of Ag-NP had decreases serum glucose level (92 and 91 ml/dl in compared with control: 109 ml/dl), and total cholesterol and triglyceride had increases following Ag-NP administration (P< 0.01). In conduction, peripherally administration of chemically-synthesized Ag-NP in 100-200 mg/Kg of BW dosages, cause hypo-glycemic and hyper-lipidemic effects, due to increases peripheral glucose and decreases total cholesterol and triglyceride levels in rat model. The administration of greater dosage may cause mortality of experimental animals. |
| Databáze: | OpenAIRE |
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