Serum periostin and TNF-α levels in patients with obstructive sleep apnea-hypopnea syndrome
| Autor: | Lei Ji, Gui-Juan Ji, Ping-li Liu, Shu-yang Zhu, Yanan Liu, Jun He, Wenhui Zhang, Bi Chen, Yu-Ying Gan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Neurology medicine.diagnostic_test business.industry medicine.medical_treatment Polysomnography Periostin medicine.disease Gastroenterology Obstructive sleep apnea 03 medical and health sciences 0302 clinical medicine Cytokine 030228 respiratory system Otorhinolaryngology Potential biomarkers Internal medicine medicine In patient Neurology (clinical) business Hypopnea 030217 neurology & neurosurgery |
| Zdroj: | Sleep and Breathing. 25:331-337 |
| ISSN: | 1522-1709 1520-9512 |
| DOI: | 10.1007/s11325-020-02124-y |
| Popis: | Obstructive sleep apnea-hypopnea syndrome (OSAHS) may cause pulmonary diseases, and periostin plays an important role on the development of pulmonary diseases. In addition, periostin and pro-inflammatory cytokine TNF-α can regulate each other in vivo. This study aimed to observe the changes of serum periostin and TNF-α levels in patients with OSAHS compared with healthy volunteers and to investigate their correlation. A convenience sample of 67 patients with OSAHS in our hospital from December 2018 to December 2019 was selected and categorized into mild, moderate, and severe groups according to apnea-hypopnea index by polysomnography. In addition, 21 healthy volunteers were selected as the control group. Serum levels of periostin and TNF-α were determined by enzyme-linked immunosorbent assay (ELISA). Results were analyzed using the SPSS software. Both serum periostin and TNF-α levels in all the three OSAHS groups were higher than those of the control group and increased with severity of OSAHS. The severe group had significantly higher serum periostin and TNF-α levels than the mild and moderate groups (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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