Establishment of a long-term adenocarcinoma of the prostate cell line in the nude mouse
| Autor: | Kenneth W. Lyles, Susan Poulton, Brett H. Woodard, J. Linder, David F. Paulson, Sam D. Graham |
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| Rok vydání: | 1985 |
| Předmět: |
medicine.medical_specialty
biology medicine.drug_class Urology Acid phosphatase medicine.disease biology.organism_classification Androgen Nude mouse medicine.anatomical_structure Endocrinology Oncology Prostate Estrogen Cell culture Internal medicine medicine biology.protein Cancer research Adenocarcinoma Hypophosphatemia |
| Zdroj: | The Prostate. 7:369-376 |
| ISSN: | 1097-0045 0270-4137 |
| Popis: | There are few established human prostatic adenocarcinoma cell lines in existence. Most established lines are nonfunctional and hormonally insensitive. A human prostate adenocarcinoma (9479) has been serially transplanted for more than 4 years in athymic nude mice. The tumor is estrogen and androgen insensitive, is transplantable between mice with a high rate of success. The tumor does not produce enzymatically measurable acid phosphatase, but does produce immunologically identifiable acid phosphatase. Not only has the tumor retained its original morphology, it also appears to produce a factor producing hypophosphatemia. Current studies in regards to the endocrinological aspects of this tumor are in progress. We propose that acid phosphatase is produced, but in an altered form. |
| Databáze: | OpenAIRE |
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