Nanovaccines for oral delivery-formulation strategies and challenges
| Autor: | Sayali Karandikar, Vishal Waybhase, Sandeep Patankar, Amit Mirani, Vandana B. Patravale |
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| Rok vydání: | 2017 |
| Předmět: |
Cellular immunity
business.industry 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Vaccination Immune system Antigen Single entity Immunology Parenteral route Medicine Nanocarriers 0210 nano-technology Antigen-presenting cell business |
| Popis: | The specialized field of research in vaccination is experiencing potential advances. The majority of the currently used vaccines are administered by parenteral route. This route poses certain inherent risks related to needle use and attracts limited patient compliance. These factors have fostered the need for assessing alternate routes including oral route. The oral route presents certain limitations like degradation of antigen(s) by the hostile GIT environment. Recently nanotechnology has been explored extensively in vaccine development. Nanoparticles can improve antigen stability by encapsulation of antigen and also potentiate immune response by specifically targeting dendritic cells and macrophages. Nanostructured carrier systems for the delivery of vaccines are emerging to be beneficial since they can codeliver multiple antigens as well as adjuvants in a single entity leading to enhanced humoral response and cellular immunity. The interaction of nanoparticles with antigen presenting cells is governed by the physicochemical properties of the nanoparticles like size, shape and charge, the key factors responsible for immunomodulation. This chapter summarizes such nanoformulation strategies for oral delivery of vaccines, which can potentially help to overcome the existing problems. Also, it briefly presents their challenges and regulatory aspects. |
| Databáze: | OpenAIRE |
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