Nutrient composition, antioxidant properties, and anti-proliferative activity of Lignosus rhinocerus Cooke sclerotium

Autor: Yeannie H Y Yap, Nget Hong Tan, Szu-Ting Ng, Azlina Abdul Aziz, Chon Seng Tan, Shin Yee Fung
Rok vydání: 2013
Předmět:
Zdroj: Journal of the Science of Food and Agriculture. 93:2945-2952
ISSN: 0022-5142
DOI: 10.1002/jsfa.6121
Popis: Background Lignosus rhinocerus (tiger milk mushroom) is an important medicinal mushroom used in Southeast Asia and China, and its sclerotium can be developed into functional food/nutraceuticals. The nutrient composition, antioxidant properties, and anti-proliferative activity of wild type and a cultivated strain of L. rhinocerus sclerotia were investigated. Results The sclerotial powder has high carbohydrate but low fat content. Interestingly, the cultivated strain contains higher amounts of protein and water-soluble substances than the wild type. Phenolic content of hot-water, cold-water, and methanol extracts of the sclerotial powders ranged from 19.32 to 29.42 mg gallic acid equivalents g−1 extract, while the ferric reducing antioxidant power values ranged from 0.006 to 0.016 mmol min−1 g−1 extract. The DPPH•, ABTS•+, and superoxide anion radical scavenging activities of the extracts ranged from 0.52 to 1.12, 0.05 to 0.20, and −0.98 to 11.23 mmol Trolox equivalents g−1 extract, respectively. Both strains exhibited strong superoxide anion radical scavenging activity comparable to rutin. The cold-water extracts exhibited anti-proliferative activity against human breast carcinoma (MCF-7) cells, with IC50 values of 206 µg mL−1 and 90 µg mL−1 for the wild type and cultivated strains, respectively. Conclusion The cultivated L. rhinocerus sclerotium has the potential to be developed into functional food/nutraceuticals. © 2013 Society of Chemical Industry
Databáze: OpenAIRE
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