Hippobutenolides A and B, two new long-chain fatty acid esters from the marine sponge Hippospongia lachne

Autor:	Hong-Yan Liu, Fan Sun, Li-Li Hong, Wei-Hua Jiao, Hou-Wen Lin, Li-Yun Liu, Xian-Xian Miao, Jie Wang, Jia-Bao Sun, Kai-Xuan Zhan
Rok vydání:	2021
Předmět:	chemistry.chemical_classification biology Organic Chemistry Fatty acid Hippospongia lachne biology.organism_classification Biochemistry respiratory tract diseases Residue (chemistry) Sponge chemistry Cell culture Drug Discovery Non small cell Long chain fatty acid Cytotoxicity
Zdroj:	Tetrahedron Letters. 84:153437
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2021.153437
Popis:	Two new fatty acid esters, hippobutenolides A (1) and B (2), featuring a long linear aliphatic chain attached to a butanolide residue, together with two known related ones (3 and 4), were isolated from the marine sponge Hippospongia lachne. The structures of all compounds were determined by extensive spectroscopic analysis and modified Mosher’s method. All isolates were evaluated for cytotoxicity against three non-small cell lung cancer (NSCLC) cells (A549, PC9, and HCC827) as well as one cisplatin-resistant NSCLC cell (A549-DDP) and two gefitinib-resistant NSCLC cells (PC9-GR and HCC827-GR). Compound 3 displayed cytotoxicity against all cell lines with IC50 values ranging from 18.86 to 33.24 μM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e141ea323a17c0717887063c06c2ff1b https://doi.org/10.1016/j.tetlet.2021.153437 Zobrazit plný text záznamu Full Text from ScienceDirect