An Investigation into the Formation of Impurity B during the Optimization of Naratriptan Hydrochloride

Autor:	V. Ravi Sankar, S. Mahender Rao, M. Pandi Prabhu, S. Bharani Kumar, U. Sampath Kumar
Rok vydání:	2009
Předmět:	Materials science Impurity Process development Acid catalyzed Organic Chemistry Naratriptan Hydrochloride Physical chemistry Physical and Theoretical Chemistry
Zdroj:	Organic Process Research & Development. 13:468-470
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op800286f
Popis:	During the process development of naratriptan hydrochloride we have made an unusual observation about the enhanced levels of intermediate 3 as an impurity (impurity B) in the final stage. Detailed investigation has led to the conclusion that impurity B is not only a carried over but also formed via acid catalyzed dehydration of yet another process related impurity. The present work details a report of the journey towards the development of an efficient process for the commercial production of naratriptan hydrochloride substantially free from the impurity B.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e1388d7914e512ec4f0e6ed650b9c999 https://doi.org/10.1021/op800286f Zobrazit plný text záznamu