Application of N-Acetylcysteine in Neurological Disorders
| Autor: | Andrei V Alexandrov, Reza Bavrsad Shahripour, Ana Hossein Zadeh Maleki |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Ataxia Subarachnoid hemorrhage Traumatic brain injury business.industry Multiple sclerosis medicine.disease Bioinformatics nervous system diseases Peripheral neuropathy Olivopontocerebellar atrophy medicine Spinocerebellar ataxia medicine.symptom Myopathy business |
| Zdroj: | The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine ISBN: 9789811053108 |
| DOI: | 10.1007/978-981-10-5311-5_11 |
| Popis: | N-Acetylcysteine (NAC), widely known as an antidote to acetaminophen overdose, is now emerging as treatment of vascular and nonvascular (degenerative and non-degenerative) neurological disorders. Not only does NAC directly enter endogenous biochemical processes, but it also may cross the blood-brain barrier, thereby enhancing its biological effect. The majority of recent published NAC studies have been carried out in animal models of various neurological disorders with only a few studies completed in humans with only a few clinical trials. Herein, we discuss potential applications of NAC in neurodegenerative diseases including spinocerebellar ataxia, Freidrich’s ataxia, ataxia–telangiectasia, Parkinson’s disease, Huntington’s disease, myoclonus epilepsy of the Unverricht–Lundborg type, multiple sclerosis, motor neuron disorders, and Alzheimer’s disease. We also discuss the application of NAC in facilitation of recovery from traumatic brain injury, cerebral ischemia, vasospasms after subarachnoid hemorrhage, peripheral neuropathy, and myopathy. This systematic review found that NAC treatment appears safe and tolerable with favorable evidence for the use of NAC in anticancer medicine-induced neuropathy. In our review (based on published studies), no recommendations could be made for most of the neurological disorders including ataxia–telangiectasia, Freidrich’s ataxia, Huntington’s disease, olivopontocerebellar atrophy, motor neuron diseases, subarachnoid hemorrhage, and traumatic brain injury. Studies on hereditary spinocerebellar ataxia, multiple sclerosis, and myoclonus epilepsy of Unverricht–Lundborg diseases demonstrated mixed results. We believe that further well-designed larger controlled trials are needed for specific neurological disorders. |
| Databáze: | OpenAIRE |
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