Association of FOXM1 expression with tumor histology and prognosis in Wilms tumor: Potential for a new prognostic marker
Autor: | Norbert Graf, Roland Kappler, Doris Mayr, Dietrich von Schweinitz, Rhoikos Furtwängler, Jochen Hubertus, Nadja Apelt |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Pathology CD30 Oncogene business.industry Cancer Tumor M2-PK Wilms' tumor Histology Malignancy medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Medicine Histopathology business |
Zdroj: | Oncology Letters. 12:2854-2859 |
ISSN: | 1792-1082 1792-1074 |
Popis: | Wilms tumor (WT) is the most common pediatric renal malignancy. A recent ontogenic model suggests that undifferentiated tumor state, and hence poor prognosis, in WT is determined by stabilization of β-catenin in the nucleus. Forkhead box M1 (FOXM1) is a downstream component of the Wnt pathway and promotes nuclear localization of β-catenin. As elevation of FOXM1 gene expression is prognostic in various types of malignancy, we hypothesized that high FOXM1 expression in WT is associated with undifferentiated histology and thus poor prognosis. In the current study, the expression of FOXM1 mRNA was determined in 46 WT specimens and 11 renal tissue controls from patients undergoing tumor nephrectomy, and these data were assessed with regard to clinicopathological parameters. The results demonstrated an upregulation of FOXM1 in WT by 10-fold compared to normal tissue. Expression differed significantly between controls and tumors of intermediate- and high-risk histopathology (P |
Databáze: | OpenAIRE |
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