| Autor: |
M. Moleón, F. Sierra, A. Navarro, C. Barreda, E. Román, J. Pastor |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Farmacia Hospitalaria. 34:23-26 |
| ISSN: |
1130-6343 |
| DOI: |
10.1016/j.farma.2009.09.003 |
| Popis: |
Objectives: Analyse renal function evolution in multiple myeloma patients after reducing infusion time for 90 mg pamidronate by 2h. Methods: In 2007, a retrospective study was carried out on all patients who presented multiple myeloma and bone metastasis treated with pamidronate administered every 4h. Following a review of the literature, a protocol for administering pamidronate every 2h was created in partnership with Haematology, and a specific dose reduction framework was established for patients with baseline renal failure. Additionally, a prospective follow-up study of those patients' renal function was completed to analyse its evolution after the change in infusion time. Results: A total of six patients received 90mg pamidronate every 4h. 33.32% of the patients (2/6) presented baseline renal insufficiency, and therefore needed to have the pamidronate dose adjusted according to the new protocol. Subsequently, all of them received the treatment every 2h, and one patient (16.6%) experienced altered renal function after two treatment cycles. Discussion: Reducing administration time for pamidronate from four to 2h did not lead to significant variations in patients' renal function. This therapeutic practice can improve patients' quality of life by shortening their hospital stay without aggravating their renal function. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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