Low-dose maternal warfarin intake resulting in fetal warfarin syndrome: In search for a safe anticoagulant regimen during pregnancy
| Autor: | Priyanka Aggarwal, Neha Kakani, Ashok Kumar, Sriparna Basu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Embryology
Pediatrics medicine.medical_specialty Heart disease medicine.drug_class 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Ductus arteriosus Medicine cardiovascular diseases 030212 general & internal medicine Fetus Pregnancy business.industry Anticoagulant Warfarin General Medicine Fetal warfarin syndrome medicine.disease Regimen medicine.anatomical_structure Pediatrics Perinatology and Child Health business Developmental Biology medicine.drug |
| Zdroj: | Birth Defects Research Part A: Clinical and Molecular Teratology. 106:142-147 |
| ISSN: | 1542-0752 |
| DOI: | 10.1002/bdra.23435 |
| Popis: | Background Fetal exposure to maternal ingestion of warfarin is known to produce certain dysmorphic features in the neonate, known as fetal warfarin syndrome (FWS). There is a general consensus that maternal intake of warfarin at a daily dose of 5 mg or less is safe both for the infant and the mother. Methods We report four cases of FWS born to mothers with rheumatic heart disease on warfarin prophylaxis during pregnancy at a dose less than 5 mg/day. Results Along with typical facial features of FWS and multiple epiphyseal stippling in skeletal x-ray, Case 1 had Dandy-Walker malformation and Case 2 had laryngo-tracheomalacia and patent ductus arteriosus. Conclusion We emphasize the need for optimizing the choice and dosage schedule of anticoagulants during pregnancy, least harmful for the mother and her developing fetus. |
| Databáze: | OpenAIRE |
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