Photoinduced Palladium-Catalyzed Intermolecular Radical Cascade Cyclization of N-Arylacrylamides with Unactivated Alkyl Bromides

Autor:	Junmin Zhang, Hongling Wang, Juan Du, Jinhu Wei, Xing Wang, Jun Song, Xuan Huang
Rok vydání:	2021
Předmět:	chemistry.chemical_classification Organic Chemistry Intermolecular force chemistry.chemical_element Reaction intermediate Biochemistry Medicinal chemistry Catalysis chemistry.chemical_compound chemistry Cascade reaction Cascade Oxindole Physical and Theoretical Chemistry Alkyl Palladium
Zdroj:	Organic Letters. 23:5631-5635
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.1c01698
Popis:	A mild visible-light-induced Pd-catalyzed intermolecular radical cascade reaction of N-arylacrylamides with unactivated alkyl bromides is disclosed. Photoexcited Pd complexes transfer a single electron in this protocol, and hybrid alkyl Pd-radical species are involved as the key reaction intermediates. Sophisticated bioactive oxindole derivatives bearing various substituents and substitution patterns can be efficiently afforded through this approach.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e114563152cceb0fb7afc4964d98cedf https://doi.org/10.1021/acs.orglett.1c01698 Zobrazit plný text záznamu