Separation of the primary and secondary kinetic isotope effects at a reactive center using starting material reactivities. Application to the FeCl3-Catalyzed oxidation of CH bonds with tert-butyl hydroperoxide

Autor:	Jason A. Smith, Steven R. Merrigan, Derek H. R. Barton, Daniel A. Singleton, Valérie N. Le Gloahec
Rok vydání:	1999
Předmět:	Primary (chemistry) Organic Chemistry Inorganic chemistry Absolute rate Kinetic energy Photochemistry Biochemistry Ethylbenzene Catalysis chemistry.chemical_compound chemistry Drug Discovery Kinetic isotope effect tert-Butyl hydroperoxide Reactive center
Zdroj:	Tetrahedron Letters. 40:3847-3850
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(99)00637-1
Popis:	A method is reported for the determination of both the primary and secondary kinetic isotope effects at a reactive center based on staring material reactivities. This allows the determination of the separate KIEs in reactions for which neither product analysis nor absolute rate measurements are applicable. The methodology is applied to the FeCl 3 -catalyzed oxidation of ethylbenzene with tert-butyl hydroperoxide, which exhibits both a primary isotope effect and a substantial secondary isotope effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e111b53ac09a4cbf1248ce0120482c00 https://doi.org/10.1016/s0040-4039(99)00637-1 Zobrazit plný text záznamu Full Text from ScienceDirect