Synthesis of chiral tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones

Autor:	Douglas C. Knorr, Howard C. Smith, Thomas Daniel Aicher
Rok vydání:	1998
Předmět:	Amidine Hydrolysis chemistry.chemical_compound chemistry Organic Chemistry Drug Discovery Diastereomer Organic chemistry Enantiomer Biochemistry
Zdroj:	Tetrahedron Letters. 39:8579-8580
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(98)01962-5
Popis:	In our investigations of potential hypoglycemic agents,2 it was desired to evaluate optically pure tetrahydropyrrolo[2,1-β]thiazol-5-ones. A novel, practical synthesis of each enantiomer of 1 via formation, separation, and hydrolysis of diastereomeric amidine derivatives is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e107883b52d6a8a6756215f222ec0b94 https://doi.org/10.1016/s0040-4039(98)01962-5 Zobrazit plný text záznamu Full Text from ScienceDirect