?-Cyanothioacetamide and its derivatives in heterocyclic synthesis: Preparation of several new 4-oxoquinazoline derivatives

Autor:	M. A. Abdel Aziz, S. M. Abdel Gawad, H. A. Daboun
Rok vydání:	1990
Předmět:	chemistry.chemical_compound Derivative (finance) chemistry Yield (chemistry) Anthranilic acid Acetonitrile Medicinal chemistry Malononitrile
Zdroj:	Journal f�r Praktische Chemie. 332:610-618
ISSN:	1521-3897 0021-8383
DOI:	10.1002/prac.19903320505
Popis:	The reaction of α-cyanothioacetamide (1) or its methylthio derivative (2) with anthranilic acid led to the formation of 3,4-dihydro-4-oxoquinazolin-2-yl acetonitrile (3). 3 condensed with aromatic aldehydes to give arylidene derivatives (4a-d) which could be prepared also via the reaction of 2-thiocarbamoylcinnamonitriles (5a-d) or their methylthio derivatives (6a-d) with anthranilic acid. 3 reacted with cinnamonitrile derivatives (7a-h) and (12a-d) to yield pyrido-[1,2-a]-quinazoline derivatives (10a-h) and (15a-d) which could also be prepared by the reaction of (4a-d) with malononitrile (11a), benzoyl acetonitrile (11b) and ethylcyanoacetate (16), respectively.
Databáze:	OpenAIRE
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