Diagnosis of herpes infection as the part of a comprehensive examination of patients with the oculomotor cranial nerves disorders

Autor:	N. G. Chopyk, I. G. Vasilyeva, V. M. Zhdanova
Rok vydání:	2019
Předmět:	medicine.medical_specialty business.industry Cranial nerves Venous blood Gastroenterology law.invention chemistry.chemical_compound chemistry law Internal medicine Etiology medicine In patient Neurosurgery business Human herpesvirus DNA Polymerase chain reaction
Zdroj:	Ukrainian Neurological Journal. :40-46
ISSN:	2522-1183 1998-4235
DOI:	10.30978/unj2019-1-40
Popis:	Objective — to study the presence of 8 human herpesvirus DNA in the venous blood of patients with oculomotor disorders (OMD) caused by dysfunction of III and/or VI cranial nerves (CN), and the effect of etiotropic treatment to the course of the disease.Methods and subjects. The work was performed on the analysis of the results of the examination of 40 patients with impaired functions of the III and/or VI CN who were administered to Romodanov Neurosurgery Institute in the period of 2016 — 2019. Patients underwent a comprehensive clinical, neurological and neuro‑ophthalmological examination, MRI or CT scan of the brain. The neurosurgical pathology was not revealed. All patients underwent the venous blood tests for HSV1/2 DNA, varicella, VZV, EBV, CMV, HHV 6.7.8. The presence of DNA of viruses of the herpes group in the blood of patients was determined using the method of polymerase chain reaction (PCR).Results. In the blood of patients with oculomotor disorders due to lesions of III and/or VI CN of unknown etiology, DNA of herpetic viruses was found: HHV7 — in 50 % of those examined, EBV — in 15 %, HHV6 — 5 %. HSV1/2 DNA detected in 1 patient, and CMV DNA was detected in 1 patient. In 22.5 % of patients (9), co‑infection with two viruses was detected; in 2 patients, DNA of three viruses was detected — EBV, HHV6, HHV7. Normalization of the functions of the CN and regression of the OMD was observed, which was accompanied by the elimination of the DNA of viruses from the blood in most of the studied cases after carrying out the corresponding etiotropic treatment.Conclusions. Research results indicate the need to perform a venous blood test using PCR for DNA herpesvirus after the exclusion of neurosurgical pathology in patients with dysfunction III and/or VI cranial nerves of an inexplicable etiology.
Databáze:	OpenAIRE
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