Cell-penetrating peptides for nanomedicine – how to choose the right peptide

Autor:	Kalina Peneva, Ilja Tabujew, Marco Lelle
Rok vydání:	2015
Předmět:	chemistry.chemical_classification Cell Biomedical Engineering Bioengineering Peptide Nanotechnology Polymeric nanoparticles Combinatorial chemistry medicine.anatomical_structure chemistry Drug delivery medicine Cell-penetrating peptide Nanomedicine
Zdroj:	BioNanoMaterials. 16
ISSN:	2193-066X 2193-0651
DOI:	10.1515/bnm-2015-0001
Popis:	More than two decades ago, a group of peptides, now known as cell-penetrating peptides, sparked the hope that the ultimate carrier molecules have been found. The high expectations for these peptides, which are reflected in their bold name, led to many disappointments due to the controversial results their utilization entailed and nowadays even their effectiveness has been called into question. In this review, we discuss the uptake mechanism and application of cell penetrating peptides as mediators for organelle specific delivery of nanocarriers, pointing out the possibilities as well as strategies of their successful utilization. Additionally, we provide an overview of the conjugation techniques usually employed for the attachment of cell penetrating peptides to quantum dots, as well as silver and gold nanoparticles, and we address the various aspects that need to be considered for the successful implementation of cell penetrating peptides for organelle-specific delivery of nanoparticles into cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e0f48fee3fbe585ef044c27edf44cdfc https://doi.org/10.1515/bnm-2015-0001 Zobrazit plný text záznamu