Regiospecific S-aminoalkylation of 5-substituted 6-hydroxy-2-thiouracil derivatives in the synthesis of structural analogs of isothiobarbamine

Autor:	P. P. Deshevov, V. V. Chapurkin, Ivan A. Novakov, M. B. Nawrozkij, O. V. Vostrikova, B. D. Korenkov, D. S. Sheikin, L. L. Brunilina, I. A. Kirillov
Rok vydání:	2021
Předmět:	Green chemistry chemistry.chemical_compound chemistry Yield (chemistry) Anhydrous Organic chemistry General Chemistry Thiouracil
Zdroj:	Russian Chemical Bulletin. 70:943-948
ISSN:	1573-9171 1066-5285
Popis:	Regiospecific S-monoaminoalkylation of 5-substituted derivatives of 6-hydroxy-2-thiouracil with free N,N-dialkyl-N-(2-chloroethyl)amines in anhydrous PriOH was described for the first time. In compliance with the rules and regulations of green chemistry, this approach was used to synthesize a number of structural analogs of isothiobarbamine in high yield and purity, which are potential synthetic actoprotectors of immediate action.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e0f2e0c0b8bca3cdfb8f112c3f1765f5 https://doi.org/10.1007/s11172-021-3171-x Zobrazit plný text záznamu Full text from SpringerLink