| Popis: |
α-Fluoro-, α-chloro and α-bromo C3-C6 carboxylic acids were separated efficiently into their enantiomers, after conversion into tert.-butylamides, on a whiskerwalled glass capillary column (40 m x 3.5 mm I.D.) coated with (R)-N-lauroyl-α-(1-napththyl)ethylamine. The resolution coefficient (α) of the derivatives of the α-F, α-Cl and α-Br acids were 1.04, 1.05-1.08 and 1.08-1.13, respectively, at 100°C. The retention indices (I) and differential Gibb's free energies of solution ▵(▵G) were calculated and both were found to increase for the acids in the order F |
