Synthesis of 4H-3-aryl-2-cyano-1,4-benzothiazine 1,1-dioxides for antiviral studies

Autor:	Andrew C. Bean, Phillip D. Wilkerson, Chad E. Stephens
Rok vydání:	2017
Předmět:	chemistry.chemical_compound Iron reduction chemistry 010405 organic chemistry Aryl Organic Chemistry Organic chemistry Benzothiazine 010402 general chemistry 01 natural sciences 0104 chemical sciences
Zdroj:	Heterocyclic Communications. 23:101-103
ISSN:	2191-0197 0793-0283
DOI:	10.1515/hc-2017-0028
Popis:	2-Cyano-substituted 1,4-benzothiazine 1,1-dioxides, required for antiviral studies, were prepared by a reductive cyclodehydration of an ortho-nitro sulfone precursor containing a pendant aryl ketone group. The ring-forming reaction also furnishes a non-cyclized benzamide as a major byproduct via an unexpected acyl transfer reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e0da1f0fa45fba5c382af2d0ff178856 https://doi.org/10.1515/hc-2017-0028 Zobrazit plný text záznamu Plný text ve formátu PDF